Complement-Targeted Therapies in Lupus

Complement in Lupus Nephritis

The complement cascade consists of a series of plasma proteins that not only play a vital role in destroying pathogens but also mediate humoral and cellular interactions within the immune system (Figure). Recent work, driven particularly by the availability of gene-targeted mice, has considerably increased our understanding of the links between the complement system and glomerular disease. In t...

Complement in Lupus Nephritis

The complement cascade consists of a series of plasma proteins that not only play a vital role in destroying pathogens but also mediate humoral and cellular interactions within the immune system (Figure). Recent work, driven particularly by the availability of gene-targeted mice, has considerably increased our understanding of the links between the complement system and glomerular disease. In t...

The Role of B-Cells and B-Cell Targeted Therapies in Lupus Nephritis

cell-Targeted Therapies in Systemic Lupus Erythematosus and ANCA-Associated Vasculitis: Current Progress Authors

Complement-targeted therapeutics in periodontitis.

Periodontitis is a prevalent oral chronic inflammatory disease which, in severe forms, may exert a major impact on systemic health. Clinical and histological observations, as well as experimental animal studies, suggest involvement of the complement system in periodontitis. However, the precise roles of the various complement components and pathways in periodontitis have only recently started t...